Addition of angiotensin II receptor blockade to maximal angiotensin-converting enzyme inhibition improves exercise capacity in patients with severe congestive heart failure.

@article{Hamroff1999AdditionOA,
  title={Addition of angiotensin II receptor blockade to maximal angiotensin-converting enzyme inhibition improves exercise capacity in patients with severe congestive heart failure.},
  author={G Hamroff and Stuart D Katz and Donna M. Mancini and I S Blaufarb and Rachel Bijou and Rakesh Patel and Guillaume Jondeau and Maria Teresa Olivari and Sabu Thomas and Thierry H le Jemtel},
  journal={Circulation},
  year={1999},
  volume={99 8},
  pages={990-2}
}
BACKGROUND Incomplete suppression of the renin-angiotensin system during long-term ACE inhibition may contribute to symptomatic deterioration in patients with severe congestive heart failure (CHF). Combined angiotensin II type I (AT1) receptor blockade and ACE inhibition more completely suppresses the activated renin-angiotensin system than either intervention alone in sodium-depleted normal individuals. Whether AT1 receptor blockade with losartan improves exercise capacity in patients with… CONTINUE READING

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Cardiovascular Genetics and Genomics

Springer International Publishing • 2018

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