Addition of an ER retention signal to the ricin A chain increases the cytotoxicity of the holotoxin.

@article{Wales1992AdditionOA,
  title={Addition of an ER retention signal to the ricin A chain increases the cytotoxicity of the holotoxin.},
  author={Richard Wales and John A. Chaddock and Lynne M. Roberts and John Michael Lord},
  journal={Experimental cell research},
  year={1992},
  volume={203 1},
  pages={1-4}
}
With the exception of diphtheria toxin, which translocates from acidified endosomes, the intracellular organelle from which the catalytic moieties of several plant and bacterial toxins enter the target cell during endocytic uptake has not been identified. We have recently proposed that some toxins may travel the entire secretory pathway in reverse, moving from the cell surface to the lumen of the ER, before entering the cytosol. Several bacterial toxins have the ER retention sequence KDEL or a… CONTINUE READING

From This Paper

Topics from this paper.
11 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…