Addition of PNU-100480 to first-line drugs shortens the time needed to cure murine tuberculosis.

  title={Addition of PNU-100480 to first-line drugs shortens the time needed to cure murine tuberculosis.},
  author={Kathy N. Williams and Steven J. Brickner and Charles Ken Stover and Tong Zhu and Adam Ogden and Rokeya Tasneen and Sandeep K Tyagi and Jacques H. Grosset and Eric Nuermberger},
  journal={American journal of respiratory and critical care medicine},
  volume={180 4},
RATIONALE We recently reported strong bactericidal activity of the oxazolidinone PNU-100480 and its ability to increase the initial bactericidal effect of various combinations of first-line tuberculosis drugs and moxifloxacin in a murine model. OBJECTIVES To investigate whether the addition of PNU-100480 to the standard first-line regimen of rifampin, isoniazid, and pyrazinamide could shorten the duration of treatment necessary to prevent relapse after treatment discontinuation. METHODS… CONTINUE READING


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The oxazolidinone PNU - 100480 has strong bactericidal and sterilizing activity in the murine model of tuberculosis [ abstract F 1 – 1163 a ]

  • K Williams, C Stover, +5 authors E Nuermberger
  • Final Program of the 48 th Annual Interscience…
  • 2008

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