Addition of Interleukin-21 for Expansion of T-Cells for Adoptive Immunotherapy of Murine Melanoma

@inproceedings{Zoon2015AdditionOI,
  title={Addition of Interleukin-21 for Expansion of T-Cells for Adoptive Immunotherapy of Murine Melanoma},
  author={Christine Kathryn Zoon and Wen Wan and Laura Graham and Harry D Bear},
  booktitle={International journal of molecular sciences},
  year={2015}
}
We previously demonstrated that interleukin (IL)-7/15 was superior to IL-2 for expansion of T cells in vitro for adoptive immunotherapy. We sought to ascertain whether IL-21 would further improve yield and therapeutic efficacy of T cells in culture. Naïve T cell receptor (TcR) transgenic splenocytes or antigen-sensitized lymph node cells were harvested from… CONTINUE READING