Addition of CpG ODN and Poly (I:C) to a standard maturation cocktail generates monocyte-derived dendritic cells and induces a potent Th1 polarization with migratory capacity.

@article{Zhu2015AdditionOC,
  title={Addition of CpG ODN and Poly (I:C) to a standard maturation cocktail generates monocyte-derived dendritic cells and induces a potent Th1 polarization with migratory capacity.},
  author={Mei Zhu and Wei Xu and Hong Su and Qiong Huang and Baolong Wang},
  journal={Human vaccines & immunotherapeutics},
  year={2015},
  volume={11 7},
  pages={1596-605}
}
Monocyte-derived dendritic cells (DCs) are used as immunoadjuvant cells in cancer vaccines and have made great progress. However, an optimal DCs subset is vital for this treatment effect, the current 'gold standard' cytokine cocktail DCs have a shortcoming in their cytokines secretion, especially IL-12p70, mainly because of the existence of PGE2. Therefore… CONTINUE READING