Addition of Adrenaline to Chloroprocaine Provides a Moderate Duration Time for Epidural Anaesthesia in Elective Caesarean Section

  title={Addition of Adrenaline to Chloroprocaine Provides a Moderate Duration Time for Epidural Anaesthesia in Elective Caesarean Section},
  author={Shanwu Feng and Y. Cao and W G Wang and Yu Sheng Liu and X F Shen},
  journal={Journal of International Medical Research},
  pages={1099 - 1107}
  • S. Feng, Y. Cao, +2 authors X. Shen
  • Published 1 June 2012
  • Medicine
  • Journal of International Medical Research
OBJECTIVE: Epidural anaesthesia using chloroprocaine with or without adrenaline and lidocaine with adrenaline were compared. METHODS: Sixty parturients undergoing elective caesarean section under epidural anaesthesia were randomized to receive 3% chloroprocaine (group C), 3% chloroprocaine with adrenaline (group CA) or 2% lidocaine with adrenaline (group LA). Onset time, duration time and various maternal, fetal and neonatal parameters were monitored. Pain was assessed using a visual analogue… 
5 Citations
Comparison of Chloroprocaine Versus Lidocaine With Epinephrine, Sodium Bicarbonate, and Fentanyl for Epidural Extension Anesthesia in Elective Cesarean Delivery: A Randomized, Triple-Blind, Noninferiority Study.
Data from the current study provide insufficient evidence to confirm that CP is non inferior to LEBF for rapid epidural extension anesthesia for CD, and further research is required to determine noninferiority.
Choice of local anaesthetic for epidural caesarean section: a Bayesian network meta‐analysis
A Bayesian network meta‐analysis of direct and indirect comparisons to rank speed of onset of the six local anaesthetics most often used epidurally for surgical anaesthesia for caesarean delivery foundRapid‐onset epidural local anaesthesia can avoid general anaesthesia in women undergoing vaginal or laparoscopic surgery.
Benefit and Harm of Adding Epinephrine to a Local Anesthetic for Neuraxial and Locoregional Anesthesia: A Meta-analysis of Randomized Controlled Trials With Trial Sequential Analyses
It is concluded that adding epinephrine to epidural local anesthetics could not decrease postoperative pain intensity by 30%, and did not impact the risk of intraoperative arterial hypotension.
Risques et bénéfices de l'ajout d'adrénaline à un anesthésique local: une méta-analyse d'études randomisées et contrôlées
Cette revue systematique examine les risques et benefices de l’adjonction d’adrenaline aux anesthesiques locaux (AL) pour l’anesthesie peridurale, intrathecale ou loco-regionale. Nous avons cherche
Hintergrund und aktueller Einsatz von Adjuvanzien für die Regionalanästhesie
The vorliegende Beitrag hat zum Ziel, Hintergrund and aktuellen Stand der Anwendung dieser Adjuvanzien zur Regionalanästhesie zu betrachten, werden einher mit zahlreichen klinischen Berichten einer deutlichen Verlängerung der lokalanästhetischen Wirkung.


Comparative maternal, fetal, and neonatal effects of chloroprocaine with and without epinephrine for epidural anesthesia in obstetrics.
It is concluded that addition of epinephrine to chloroprocaine during epidural anesthesia in the normal parturient has no adverse effects on mother, fetus, neonate, or the progress of labor and that it significantly prolongs the duration of anesthesia.
The Effect of Epidural Fentanyl on the Minimum Local Analgesic Concentration of Epidural Chloroprocaine in Labor
The addition of epidural fentanyl 3 micro g/mL (60 micro g) resulted in a significant 40% reduction in the MLAC of chloroprocaine in the first stage of labor.
Comparison of bupivacaine and 2-chloroprocaine for spinal anesthesia for outpatient surgery: a double-blind randomized trial
Spinal 2-chloroprocaïne provides adequate duration and depth of surgical anesthesia for short procedures with the advantages of faster block resolution and earlier hospital discharge compared with spinal bupivacaine.
Plasma Levels of 2-Chloroprocaine in Obstetric Patients and Their Neonates after Epidural Anesthesia
Data suggest that the decreased activities of maternal and neonatal cholinesterases at term are adequate to hydrolyze most, but not all, of the plasma 2-chloroprocaine following epidural anesthesia during labor.
Spinal 2-Chloroprocaine: A Comparison with Lidocaine in Volunteers
Reliable sensory and motor blockade with predictable duration and minimal side effects make chloroprocaine an attractive choice for outpatient spinal anesthesia.
Similar onset time of 2‐chloroprocaine and lidocaine + epinephrine for epidural anesthesia for elective Cesarean section
A prospective, randomized, double‐blind trial is performed to examine the speed of onset and anesthetic quality of 2‐chloroprocaine vs. a solution of lidocaine with one additive, epinephrine 5 µg/ml.
Spinal 2-Chloroprocaine: The Effect of Added Clonidine
It is concluded that small-dose clonidine increases the duration and improves the quality of 2-CP spinal anesthesia without systemic side effects.
Spinal 2-Chloroprocaine: A Comparison with Procaine in Volunteers
Spinal 2-CP (30 mg) may be a better choice for short outpatient procedures because it provides anesthesia with similar efficacy as procaine (80 mg) but with more rapid fulfillment of discharge criteria.
Fetal acidosis, 2-chloroprocaine, and epidural anesthesia for cesarean section.
The pharmacologic results did not demonstrate a statistical difference in the concentration of 2-chloroprocaine or chloroaminobenzoic acid in the maternal vein or umbilical cord vein at delivery between the two groups, and suggest that 2- chloroprocane may be the drug of choice when fetal acidosis or distress is anticipated.
Spinal 2-Chloroprocaine: A Comparison with Small-Dose Bupivacaine in Volunteers
It is concluded that spinal 2-CP provides adequate duration and density of block for ambulatory surgical procedures, and has significantly faster resolution of block and return to ambulation compared with 7.5 mg of bupivacaine.