Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)

@inproceedings{Dougados2013AddingTO,
  title={Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)},
  author={Maxime R Dougados and Karsten Kissel and Tom Sheeran and Paul Peter Tak and Philip G Conaghan and Emilio - Martin Mola and Georg Schett and Howard Amital and Federico Navarro-Sarabia and Antony Hou and Corrado Bernasconi and T W F Huizinga},
  booktitle={Annals of the rheumatic diseases},
  year={2013}
}
OBJECTIVE In patients with active rheumatoid arthritis (RA) despite methotrexate, to compare the efficacy of adding tocilizumab to that of switching to tocilizumab monotherapy. METHODS Double-blind, 2-year study in which adults with active RA (DAS28 >4.4) despite methotrexate were randomly assigned either to continue methotrexate with the addition of tocilizumab (MTX+TCZ) 8 mg/kg every 4 weeks or switch to tocilizumab and placebo (TCZ+PBO). The primary endpoint was the DAS28-erythrocyte… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 168 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 103 extracted citations

169 Citations

0102030'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 169 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 24 references

American College of Rheumatology / European League against Rheumatism provisional defi nition of remission in rheumatoid arthritis for clinical trials

DT Felson, JS Smolen, G Wells
Ann Rheum Dis • 2011