Adding growth factors or interleukin-3 to erythropoietin has limited effects on anemia of transfusion-dependent patients with myelodysplastic syndromes unresponsive to erythropoietin alone.

@article{Musto2001AddingGF,
  title={Adding growth factors or interleukin-3 to erythropoietin has limited effects on anemia of transfusion-dependent patients with myelodysplastic syndromes unresponsive to erythropoietin alone.},
  author={Pellegrino Musto and Grazia Sanpaolo and Giovanni D'Arena and Potito Rosario Scalzulli and Roberta Matera and Antonietta Falcone and Carlo Bodenizza and Gianni Perla and Marco Carotenuto},
  journal={Haematologica},
  year={2001},
  volume={86 1},
  pages={44-51}
}
BACKGROUND AND OBJECTIVES Recombinant erythropoietin (r-EPO) induces erythroid responses in patients affected by myelodysplastic syndromes (MDS). However, the response rate declines to 10-15% in MDS with substantial transfusion needs. Both in vitro and in vivo studies have suggested that the addition of growth factors (G-CSF, GM-CSF) or interleukin-3 (IL-3) may potentiate the effect of r-EPO on dysplastic erythropoiesis. The aim of this study was to evaluate the effects of the combination of r… CONTINUE READING

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