Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences.

@article{Shete2003AddingFP,
  title={Adding further power to the Haseman and Elston method for detecting linkage in larger sibships: weighting sums and differences.},
  author={Sanjay S. Shete and Kevin B. Jacobs and Robert C. Elston},
  journal={Human heredity},
  year={2003},
  volume={55 2-3},
  pages={
          79-85
        }
}
Haseman and Elston (H-E) proposed a robust test to detect linkage between a quantitative trait and a genetic marker. In their method the squared sib-pair trait difference is regressed on the estimated proportion of alleles at a locus shared identical by descent by sib pairs. This method has recently been improved by changing the dependent variable from the squared difference to the mean-corrected product of the sib-pair trait values, a significantly positive regression indicating linkage… CONTINUE READING
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