Addiction of MYCN Amplified Tumours to B-MYB Underscores a Reciprocal Regulatory Loop

@inproceedings{Gualdrini2010AddictionOM,
  title={Addiction of MYCN Amplified Tumours to B-MYB Underscores a Reciprocal Regulatory Loop},
  author={Francesco Gualdrini and Daisy Corvetta and Sandra Cantilena and Olesya Chayka and Barbara Tanno and Giuseppe Raschell{\'a} and Arturo Sala},
  booktitle={Oncotarget},
  year={2010}
}
MYCN is a member of the MYC family of oncoproteins frequently amplified or overexpressed in aggressive, paediatric tumours of the nervous system. In this study we have identified the gene B-MYB, encoding the transcription factor also known as MYBL2, as a downstream target of MYCN. Using multiple in silico databases we show that expression of B-MYB significantly correlates with that of MYCN in neuroblastoma patients. MYCN binds to and activates the B-MYB gene in vivo and in vitro. Blunting B-MYB… CONTINUE READING
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