Addiction is a brain disease, and it matters.
@article{Leshner1997AddictionIA, title={Addiction is a brain disease, and it matters.}, author={Alan Leshner}, journal={Science}, year={1997}, volume={278 5335}, pages={ 45-7 } }
Scientific advances over the past 20 years have shown that drug addiction is a chronic, relapsing disease that results from the prolonged effects of drugs on the brain. As with many other brain diseases, addiction has embedded behavioral and social-context aspects that are important parts of the disorder itself. Therefore, the most effective treatment approaches will include biological, behavioral, and social-context components. Recognizing addiction as a chronic, relapsing brain disorder…
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References
SHOWING 1-10 OF 27 REFERENCES
Molecular mechanisms of drug reinforcement and addiction.
- Psychology, BiologyAnnual review of neuroscience
- 1995
Drug reinforcement is a form of behavioral plasticity in which behavioral changes occur in response to acute exposure to a reinforcing drug, and the addicted state are both characterized by an increase in drug-seeking behavior.
The neural basis of drug craving: An incentive-sensitization theory of addiction
- Psychology, BiologyBrain Research Reviews
- 1993
Substance Abuse: A Comprehensive Textbook
- Medicine, Psychology
- 1992
This book discusses the determinants and perpetuators of substance abuse, medical aspects of immunodeficiency virus infections and its treatment in injecting drug users, and management of the psychosocial sequelae of Hiv infection among drug users effects of narcotics on immune function.
Activation of memory circuits during cue-elicited cocaine craving.
- Psychology, BiologyProceedings of the National Academy of Sciences of the United States of America
- 1996
Correlations of metabolic increases in the dorsolateral prefrontal cortex, medial temporal lobe, and cerebellum with self-reports of craving suggest that a distributed neural network, which integrates emotional and cognitive aspects of memory, links environmental cues with cocaine craving.
Drugs of abuse: anatomy, pharmacology and function of reward pathways.
- Biology, PsychologyTrends in pharmacological sciences
- 1992
Effects of chronic cocaine abuse on postsynaptic dopamine receptors.
- Psychology, MedicineThe American journal of psychiatry
- 1990
It is concluded that postsynaptic dopamine receptor availability decreases with chronic cocaine abuse but may recover after a drug-free interval.
Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system
- BiologySynapse
- 1995
It is shown that chronic ethanol treatment increased levels of tyrosine hydroxylase and glial fibrillary acidic protein immunoreactivity, and decreases levels of neurofilament protein immunOREactivity, in the VTA.
Integrating systemic cue exposure with standard treatment in recovering drug dependent patients.
- Psychology, BiologyAddictive behaviors
- 1990
Corticotropin releasing factor, stress and behavior
- Biology, Psychology
- 1994
The results suggest that endogenous CRF systems in the brain may have a role in mediating behavioral responses to stressors, and may be particularly important in situations where an organism must mobilize not only the pituitary adrenal system, but also the central nervous system in response to environmental challenge.