Addiction, Dopamine, and the Molecular Mechanisms of Memory

@article{Berke2000AddictionDA,
  title={Addiction, Dopamine, and the Molecular Mechanisms of Memory},
  author={Joshua D. Berke and Steven E. Hyman},
  journal={Neuron},
  year={2000},
  volume={25},
  pages={515-532}
}

Figures and Tables from this paper

Two-shot cocktail: Adenosine, dopamine and a twist of βγ
TLDR
New research suggests that ethanol interacts synergistically with adenosine and dopamine signaling to amplify the effect of drinking.
Total Recall--the Memory of Addiction
TLDR
Discussing a paper from Malenka and colleagues published elsewhere, Nestler compares the increase in glutamatergic transmission accompanying LTP in the hippocampus with that induced in VTA dopamine neurons by cocaine.
Molecular basis of long-term plasticity underlying addiction
TLDR
In Box 1, two parts of the text read 'histone acetylase activity' should have read ' historical acetylation'.
Late decrease of pCREB in the Basolateral Amygdala by Social Interaction Reward
  • R. E. Rawas
  • Biology, Psychology
    Biomedical Journal of Scientific & Technical Research
  • 2019
The transcription factor CREB (cAMP response element-binding protein) has been shown to be activated by drugs of abuse in reward-related brain regions...
THE EFFECTS OF LOBELINE ON METHAMPHETAMINE-INDUCED CONDITIONED PLACE PREFERENCE AND DOPAMINERGIC ALTERATIONS IN THE NUCLEUS ACCUMBENS SHELL
TLDR
The next generation of teachers will have to think differently about how to teach and how to promote positive emotions in the classroom.
The ins of the striatum: Utilizing chemogenetics to define the contribution of cortical and thalamic afferents during addiction behaviors
TLDR
The ins of the striatum: Utilizing chemogenetics to define the role of cortical and thalamic afferents during addiction behavior and its role in addiction behavior is defined.
A Behavioral/Systems Approach to the Neuroscience of Drug Addiction
  • F. J. White
  • Psychology, Biology
    The Journal of Neuroscience
  • 2002
Drug addiction is likely to affect all of our lives, with any luck not through our own actions but probably because of one or more of our family and friends. Now firmly entrenched as a brain disease
Unmet expectations: The brain minds
TLDR
New work shows that the frustration of not receiving drugs when they are expected can also affect the inner workings of reward circuits.
Regulation of dopaminergic neuron firing by heterogeneous dopamine autoreceptors in the substantia nigra pars compacta
J. Neurochem. (2011) 116, 966–974.
...
...

References

SHOWING 1-10 OF 364 REFERENCES
Neuroscience of Addiction
Neurobehavioural mechanisms of reward and motivation
Drug addiction: bad habits add up
TLDR
Researchers are addressing the causes of addiction by addressing the brain-learning systems concerned, with the intent of developing better treatments.
A Model of How the Basal Ganglia Generate and Use Neural Signals That Predict Reinforcement
TLDR
This chapter contains sections titled: Introduction, Dopamine Neurons, Organization of Strtosomal Modules, Mechanism of Responsiveness to Predictors of Reinforcement, Correspondence with the Theory of Adaptive Critics, and Relation to the Actor-Critic Architecture.
Drug abuse: hedonic homeostatic dysregulation.
TLDR
This framework provides a realistic approach to identifying the neurobiological factors that produce vulnerability to addiction and to relapse in individuals with a history of addiction.
Effect of nigrostriatal dopamine depletion on the post-training, memory-improving action of amphetamine.
  • N. White
  • Biology, Psychology
    Life sciences
  • 1988
Synaptic Runaway in Associative Networks and the Pathogenesis of Schizophrenia
TLDR
It turns out that synaptic runaway is of fairly moderate magnitude in binary-firing associative memory networks under normal, baseline conditions, however, it may become extensive if the threshold for Hebbian learning is reduced.
Cocaine addiction: psychology and neurophysiology.
TLDR
Clinical and preclinical investigations demonstrate that cocaine produces unique abuse and withdrawal patterns that differ from those of other major abused drugs and suggest that long-term cocaine abuse produces neurophysiological alterations in specific systems in the central nervous system that regulate the capacity to experience pleasure.
...
...