Adderall® produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers

  title={Adderall{\textregistered} produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers},
  author={B. Matthew Joyce and Paul E. A. Glaser and Greg A. Gerhardt},
RationaleAdderall® is currently used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD) and is composed of a novel mixture of approximately 24% l-amphetamine and 76% d-amphetamine salts. There are, however, no investigations of the pharmacological effects of this combination in vivo.ObjectivesThe technique of high-speed chronoamperometry using Nafion®-coated single carbon-fiber microelectrodes was used to study amphetamine-evoked dopamine (DA) release produced by Adderall®, d… 

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  • R. KuczenskiD. Segal
  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 2001
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