Add-on Pyridostigmine Enhances CD4+ T-Cell Recovery in HIV-1-Infected Immunological Non-Responders: A Proof-of-Concept Study

@inproceedings{ValdsFerrer2017AddonPE,
  title={Add-on Pyridostigmine Enhances CD4+ T-Cell Recovery in HIV-1-Infected Immunological Non-Responders: A Proof-of-Concept Study},
  author={S I Vald{\'e}s-Ferrer and Jos{\'e} Carlos Crisp{\'i}n and Pablo F Belaunzar{\'a}n-Zamudio and Carlos A. Rodr{\'i}guez-Osorio and Bernardo Cacho-D{\'i}az and Jorge Alcocer-Varela and Carlos Gerardo Cant{\'u}-Brito and Juan Gerardo Sierra-Madero},
  booktitle={Front. Immunol.},
  year={2017}
}
Background In human immunodeficiency virus (HIV)-infection, persistent T-cell activation leads to rapid turnover and increased cell death, leading to immune exhaustion and increased susceptibility to opportunistic infections. Stimulation of the vagus nerve increases acetylcholine (ACh) release and modulates inflammation in chronic inflammatory conditions, a neural mechanism known as the cholinergic anti-inflammatory pathway (CAP). Pyridostigmine (PDG), an ACh-esterase inhibitor, increases the… CONTINUE READING
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