Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.

@article{Lee2008AdaptorPS,
  title={Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.},
  author={Jiyeon Lee and Cl{\'a}udio Andr{\'e}s Retamal and Loreto Cuiti{\~n}o and Amy L Caruano-Yzermans and J Shin and Peter van Kerkhof and M P Marzolo and Guojun Bu},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 17},
  pages={11501-8}
}
Accumulation of extracellular amyloid beta peptide (Abeta), generated from amyloid precursor protein (APP) processing by beta- and gamma-secretases, is toxic to neurons and is central to the pathogenesis of Alzheimer disease. Production of Abeta from APP is greatly affected by the subcellular localization and trafficking of APP. Here we have identified a novel intracellular adaptor protein, sorting nexin 17 (SNX17), that binds specifically to the APP cytoplasmic domain via the YXNPXY motif that… CONTINUE READING