Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress.

@article{Fidalgo2012AdaptorPC,
  title={Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress.},
  author={Miguel Fidalgo and Ana Guerrero and Mar{\'i}a Gago – Fraile and Cristina Iglesias and Celia M. Pombo and Juan Zalvide},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 14},
  pages={11556-65}
}
While studying the functions of CCM3/PDCD10, a gene encoding an adaptor protein whose mutation results in vascular malformations, we have found that it is involved in a novel response to oxidative stress that results in phosphorylation and activation of the ezrin/radixin/moesin (ERM) family of proteins. This phosphorylation protects cells from accidental cell death induced by oxidative stress. We also present evidence that ERM phosphorylation is performed by the GCKIII kinase Mst4, which is… CONTINUE READING