Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src.

@article{Sato2002AdaptorPS,
  title={Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src.},
  author={Ken-ichi Sato and Tomomi Nagao and Miki Kakumoto and Miwa Kimoto and Tetsuji Otsuki and Tetsushi Iwasaki and Alexander A. Tokmakov and Koji M. Owada and Yasuo Fukami},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 33},
  pages={29568-76}
}
The activity of c-Src protein-tyrosine kinase is up-regulated under a number of receptor signaling pathways. However, the activation mechanism of c-Src under physiological conditions has remained unclear. We show here that the Shc adaptor protein is a novel direct activator of c-Src in epidermal growth factor receptor signaling in A431 human epidermoid carcinoma cells. Among the three Shc isoforms, P66 and P52, but not P46, were found to interact with and activate c-Src in vitro and in vivo… CONTINUE READING

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