Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation.

  title={Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation.},
  author={Sampriti Mukherjee and Anna C Bree and Jing Liu and Joyce E. Patrick and P. Monica Chien and Daniel B Kearns},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 1},
The Lon AAA+ protease is a highly conserved intracellular protease that is considered an anticancer target in eukaryotic cells and a crucial virulence regulator in bacteria. Lon degrades both damaged, misfolded proteins and specific native regulators, but how Lon discriminates among a large pool of candidate targets remains unclear. Here we report that Bacillus subtilis LonA specifically degrades the master regulator of flagellar biosynthesis SwrA governed by the adaptor protein swarming… CONTINUE READING
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