Adaptively inferring human transcriptional subnetworks

  title={Adaptively inferring human transcriptional subnetworks},
  author={Debopriya Das and Zaher Nahl{\'e} and Michael Q Zhang},
  journal={Molecular Systems Biology},
  pages={2006.0029 - 2006.0029}
Although the human genome has been sequenced, progress in understanding gene regulation in humans has been particularly slow. Many computational approaches developed for lower eukaryotes to identify cis-regulatory elements and their associated target genes often do not generalize to mammals, largely due to the degenerate and interactive nature of such elements. Motivated by the switch-like behavior of transcriptional responses, we present a systematic approach that allows adaptive determination… CONTINUE READING


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