Adaptive walks on high-dimensional fitness landscapes and seascapes with distance-dependent statistics

@article{Agarwala2018AdaptiveWO,
  title={Adaptive walks on high-dimensional fitness landscapes and seascapes with distance-dependent statistics},
  author={Atish Agarwala and Daniel S. Fisher},
  journal={bioRxiv},
  year={2018}
}
The dynamics of evolution is intimately shaped by epistasis — interactions between genetic elements which cause the fitness-effect of combinations of mutations to be non-additive. Analyzing evolutionary dynamics that involves large numbers of epistatic mutations is intrinsically difficult. A crucial feature is that the fitness landscape in the vicinity of the current genome depends on the evolutionary history. A key step is thus developing models that enable study of the effects of past… 
Epistasis and Adaptation on Fitness Landscapes
Epistasis occurs when the effect of a mutation depends on its carrier’s genetic background. Despite increasing evidence that epistasis for fitness is common, its role during evolution is contentious.
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The 2022 Feldman Prize

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