Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage.

@article{Lugea2011AdaptiveUP,
  title={Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage.},
  author={Aurelia Lugea and David Tischler and Janie D Nguyen and Jun Gong and I. Ya. Gukovsky and Samuel William French and Fred S. Gorelick and Stephen J Pandol},
  journal={Gastroenterology},
  year={2011},
  volume={140 3},
  pages={
          987-97
        }
}
BACKGROUND & AIMS Endoplasmic reticulum (ER) stress responses (collectively known the unfolded protein response [UPR]) have important roles in several human disorders, but their contribution to alcoholic pancreatitis is not known. We investigated the role of X-box binding protein 1 (XBP1), a UPR regulator, in prevention of alcohol-induced ER stress in the exocrine pancreas. METHODS Wild-type and Xbp1(+/-) mice were fed control or ethanol diets for 4 weeks. Pancreatic tissue samples were then… CONTINUE READING
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