Adaptive two-stage analysis of genetic association in case-control designs.

Abstract

We study a two-stage analysis of genetic association for case-control studies. In the first stage, we compare Hardy-Weinberg disequilibrium coefficients between cases and controls and, in the second stage, we apply the Cochran- Armitage trend test. The two analyses are statistically independent when Hardy-Weinberg equilibrium holds in the population, so all… (More)

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Cite this paper

@article{Zheng2007AdaptiveTA, title={Adaptive two-stage analysis of genetic association in case-control designs.}, author={Gang Zheng and Kijoung Song and Robert C. Elston}, journal={Human heredity}, year={2007}, volume={63 3-4}, pages={175-86} }