Adaptive thermogenesis in adipocytes: is beige the new brown?

@article{Wu2013AdaptiveTI,
  title={Adaptive thermogenesis in adipocytes: is beige the new brown?},
  author={Jun Wu and Paul Cohen and Bruce M. Spiegelman},
  journal={Genes \& development},
  year={2013},
  volume={27 3},
  pages={
          234-50
        }
}
One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat. In addition to classical brown adipose tissue, the last few years have seen great advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fat. A deeper… 
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Recent advances in the understanding of neuronal, hormonal, and metabolic regulation of the development and activation of beige adipocytes are discussed, with a focus on the regulation of bege adipocytes by other organs, tissues, and cells.

Brown and Beige Fat: Physiological Roles beyond Heat Generation.

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Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease.

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This review summarizes the current knowledge regarding WAT browning, with a special focus on the beige adipocyte plasticity, collectively referring to a bidirectional transition between thermogenic active and latent states in response to environmental changes.

Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway.

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A next step toward the goal of promoting BAT thermogenesis by pharmacological approaches necessitates a better understanding of the enzymatic components and signaling pathways for brown and beige adipocyte development, with a special emphasis on the PRDM16 transcriptional pathway.

A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis.

The next challenge will be to develop strategies for activating BAT thermogenesis in adult humans to increase whole-body energy expenditure.

Brown adipose tissue and thermogenesis

Preclinical observations have gained additional significance with the recent discovery that active BAT is present in adult humans and can be detected by 18fluor-deoxy-glucose positron emission tomography coupled with computed tomography.

Brown and beige fat: the metabolic function, induction, and therapeutic potential

Secretary factors including BMPs can induce the development, the activation of brown or beige adipose tissue, which seem to be promising for therapeutic development.
...

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