Adaptive support ventilation may deliver unwanted respiratory rate-tidal volume combinations in patients with acute lung injury ventilated according to an open lung concept.

@article{Dongelmans2011AdaptiveSV,
  title={Adaptive support ventilation may deliver unwanted respiratory rate-tidal volume combinations in patients with acute lung injury ventilated according to an open lung concept.},
  author={Dave A. Dongelmans and Frederique Paulus and Denise P. Veelo and Jan M. Binnekade and Margreeth B. Vroom and Marcus J. Schultz},
  journal={Anesthesiology},
  year={2011},
  volume={114 5},
  pages={
          1138-43
        }
}
BACKGROUND With adaptive support ventilation, respiratory rate and tidal volume (V(T)) are a function of the Otis least work of breathing formula. We hypothesized that adaptive support ventilation in an open lung ventilator strategy would deliver higher V(T)s to patients with acute lung injury. METHODS Patients with acute lung injury were ventilated according to a local guideline advising the use of lower V(T) (6-8 ml/kg predicted body weight), high concentrations of positive end-expiratory… 
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21 Citations
Background Citations
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Methods Citations
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21 Citations

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Citation Type

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This study investigated whether AVM2 reduces VT, mechanical power, and driving pressure (ΔPstat) and provides similar gas exchange when compared to adaptive mechanical ventilation based on Otis’ equation and found a significant reduction in VT.
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Proportional assist ventilation and neutrally adjusted ventilatory assist are unique modes of ventilation that provide ventilator support in direct proportion to patient effort and therefore may be able to better match patient need and improve comfort.
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Experimental blunt chest trauma – cardiorespiratory effects of different mechanical ventilation strategies with high positive end-expiratory pressure: a randomized controlled study
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In this model of ARDS following unilateral blunt chest trauma, HFPPV ventilation improved respiratory function and fulfilled relevant ventilation endpoints for trauma patients, i.e. restoration of oxygenation and lung aeration while avoiding hypercapnia and respiratory acidosis.
Approaches to ventilation in intensive care.
TLDR
Compared to conventional lung-protecting modes of mechanical ventilation, the modern modes of ventilation presented here are further developments that optimize lung protection while improving pulmonary function and the synchrony of the patient with the ventilator.
Adaptive support ventilation for complete ventilatory support in acute respiratory distress syndrome: A pilot, randomized controlled trial
TLDR
The aim of this pilot, randomized clinical trial was to compare the outcomes of ASV versus volume‐cycled ventilation (VCV) in ARDS.
Effort-adapted modes of assisted breathing
  • O. Moerer
  • Medicine
    Current opinion in critical care
  • 2012
TLDR
There is growing evidence that supports the physiological concept of closed-loop effort-adapted assisted modes of mechanical ventilation, but at present, the translation into a clear outcome benefit remains to be proven.
Novel modes of mechanical ventilation.
TLDR
Challenges facing clinicians in providing mechanical ventilatory support are focused on and several novel approaches introduced over the last 2 decades in the context of these challenges are assessed.
Spontaneous breathing activity in acute lung injury and acute respiratory distress syndrome
TLDR
In the opinion, spontaneous breathing activity should be avoided in the first 48 h of mechanical ventilation in patients with severe ARDS (PaO2/FIO2 <120 mmHg), but it may be useful in less severe AR DS and ALI.
Tidal Volume and Plateau Pressure Use for Acute Lung Injury From 2000 to Present: A Systematic Literature Review*
TLDR
For clinicians treating acute lung injury since 2000, achieving VT less than or equal to 6 mL/kg predicted body weight may not have been as attainable or important as PPlat less than and equal to 30 cm H2O.
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