Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

  title={Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing},
  author={Mukund Gupta and Bibhu Ranjan Sarangi and Joran Deschamps and Yasaman Nematbakhsh and Andrew Callan-Jones and Felix Martin Margadant and Ren{\'e} Marc M{\`e}ge and Chwee Teck Lim and Rapha{\"e}l Voituriez and Beno{\^i}t Ladoux},
  booktitle={Nature communications},
Matrix rigidity sensing regulates a large variety of cellular processes and has important implications for tissue development and disease. However, how cells probe matrix rigidity, and hence respond to it, remains unclear. Here, we show that rigidity sensing and adaptation emerge naturally from actin cytoskeleton remodelling. Our in vitro experiments and theoretical modelling demonstrate a biphasic rheology of the actin cytoskeleton, which transitions from fluid on soft substrates to solid on… CONTINUE READING
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