Adaptive responses of gamma-aminobutyric acid neurons in the ventral tegmental area to chronic ethanol.

@article{Gallegos1999AdaptiveRO,
  title={Adaptive responses of gamma-aminobutyric acid neurons in the ventral tegmental area to chronic ethanol.},
  author={Roger A Gallegos and Robert S. Lee and Jos{\'e} Ramon Criado and Steven J. Henriksen and Scott C Steffensen},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={291 3},
  pages={1045-53}
}
We have recently identified a homogeneous population of gamma-aminobutyric acid (GABA)-containing neurons in the ventral tegmental area (VTA), an area implicated in the reinforcing properties of alcohol. We evaluated the effects of local and systemic ethanol on VTA GABA neuron spontaneous activity in ethanol naive and chronically treated freely behaving rats and in anesthetized rats. In freely behaving animals, acute i.p. administration of 0.2 to 2.0 g/kg ethanol reduced the firing rate of VTA… CONTINUE READING

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