Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide.

@article{Thom2000AdaptiveRA,
  title={Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide.},
  author={Stephen R. Thom and Donald A Fisher and Y Anne Xu and Kathleen L. Notarfrancesco and Harry Ischiropoulos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 3},
  pages={1305-10}
}
Prior studies have shown that exposure to carbon monoxide (CO) will elevate the steady-state concentration of nitric oxide ((.)NO) in several cell types and body organs and that some toxic effects of CO are directed toward endothelial cells. Studies reported in this paper were conducted with bovine pulmonary artery endothelial cells exposed to 10 to 100 ppm CO to achieve concentrations between 11 and 110 nM in air-saturated buffer. Exposure to 11 nM CO increased synthesis of manganous… CONTINUE READING

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