Adaptive response of escherichia coli to alkylation damage

@article{Volkert1988AdaptiveRO,
  title={Adaptive response of escherichia coli to alkylation damage},
  author={Michael R Volkert},
  journal={Environmental and Molecular Mutagenesis},
  year={1988},
  volume={11}
}
  • M. Volkert
  • Published 1988
  • Biology, Medicine
  • Environmental and Molecular Mutagenesis
Treatment of cells with low levels of alkylating agents for extended periods of time causes them to become resistant to the lethal and mutagenic effects of subsequent high‐level challenge treatments with alkylating agents. This increased resistance has been called the adaptive response to alkylation damage and results from the induction of an alkylation‐specific DNA repair response. The adaptive response is most efficiently induced by methylating agents and is most effective against the lethal… Expand
Expression of DNA damage-inducible genes of Escherichia coli upon treatment with methylating, ethylating and propylating agents.
TLDR
It is found that the Ada-regulated adaptive response genes (ada-alkB, alkA and aidB) are induced primarily in response to methylation treatment, and the ada-independent aidC gene is induced upon treatment with agents that alkylate predominantly by SN1 nucleophilic attack. Expand
Molecular signal for induction of the adaptive response to alkylation damage in Escherichia coli.
  • B. Sedgwick
  • Biology, Medicine
  • Journal of cell science. Supplement
  • 1987
TLDR
It is found that the Ada protein is converted to an activator of expression of genes involved in the adaptive response after accepting a methyl group from a methylphosphotriester, but not from O6-methylguanine. Expand
Molecular mechanisms of adaptive response to alkylating agents in Escherichia coli and some remarks on O(6)-methylguanine DNA-methyltransferase in other organisms.
  • K. Kleibl
  • Biology, Medicine
  • Mutation research
  • 2002
TLDR
This review summarises the nature of alkylation damage in DNA and the current knowledge about the adaptive response in E. coli and includes a brief mention of MTases from other organisms with the emphasis on the human MTase, which could play a crucial role in both cancer prevention and cancer treatment. Expand
Widespread adaptive response against environmental methylating agents in microorganisms.
TLDR
The existence of adaptive responses in diverged bacterial species suggests the frequent occurrence of methylating agents in the environment, including abundantly occurring methyl chloride, the antibiotic streptozotocin, the precursors of the known labile inducers N-methyl-N'nitrosourea and N- methyl-N'-nitro-N-nitrosoguanidine and methyl radicals which may arise by the irradiation or oxidation of methyl compounds. Expand
Inducible repair of alkylated DNA in microorganisms.
TLDR
In vivo and in silico analysis of various microorganisms shows the widespread existence and versatile organization of Ada regulon genes, including not only ada, alkA, alkB, and aidB but also COG3826, alkD, and other genes whose roles in repair of alkylated DNA remain to be elucidated. Expand
Mutagenesis and DNA repair for alkylation damages in Escherichia coli k‐12
TLDR
It is proposed that the biological significance of the ogt protein relies mainly on its ability to prevent mutagenesis by low levels of bulkier ethylation products (especially in the absence of uvr excision repair). Expand
Altered induction of the adaptive response to alkylation damage in Escherichia coli recF mutants
  • M. Volkert
  • Medicine, Biology
  • Journal of bacteriology
  • 1989
TLDR
It was found that recF+ is required for normal induction of the adaptive response to alkylation damage, and this leads to the hypothesis that methylation hypermutability results from the effects of recF mutations on the induction of both the SOS response and the adaptiveresponse. Expand
Preferential DNA damage prevention by the E. coli AidB gene: A new mechanism for the protection of specific genes.
TLDR
The role of AidB is identified in alkylating agent exposed cells and a new cellular strategy in which a subset of the genome is preferentially protected from damage by alkyLating agents is suggested. Expand
Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes.
TLDR
The induction of MGMT and other genes encoding enzymes involved in DNA alkylation damage repair may be relevant in cancer therapy by causing resistance of tumor cells to alkylating drugs. Expand
Quasi-Adaptive Response to Alkylating Agents in Escherichia coli: A New Phenomenon
TLDR
The new phenomenon extends the functional range of NO compounds to include a role in genetic signal transduction within the Ada response system in addition to similar roles in the SoxRS, SOS, and OxyR systems in E. coli. Expand
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References

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Molecular Signal for Induction of the Adaptive Response to Alkylation Damage in Esherichia Coli
TLDR
It is found that the Ada protein is converted to an activator of expression of genes involved in the adaptive response after accepting a methyl group from a methylphosphotriester, but not from O6-methylguanine. Expand
Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents
The resistance of Escherichia coli to simple alkylating agents, for example N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), is markedly increased in cells previously exposed to low doses of the agents.Expand
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA
TLDR
It is reported that O6-MeG disappears from alkylated DNA after incubation with a crude enzyme fraction from adapted cells, although no concomitant release of the methyl group or theAlkylated base or nucleotide occurs, due to a previously unrecognised DNA repair mechanism involving enzyme-catalysed structural alteration of the alkylations. Expand
Adaptation to alkylation resistance involves the induction of a DNA glycosylase
TLDR
The data presented here show that killing adaptation can be ascribed to the induction of a DNA glycosylase, which releases the alkylation product 3-methyladenine from DNA in vitro as does the constitutive m3A DNA glyCosylase previously characterized by Riazuddin and Lindahl. Expand
Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.
TLDR
Antibodies raised against homogeneous O6‐methylguanine‐DNA methyltransferase (the main repair activity for mutagenic damage in alkylated DNA) were found to cross‐react with this 37‐kd protein. Expand
A common mechanism for repair of O6-methylguanine and O6-ethylguanine in DNA.
TLDR
The mutagenic effects of several ethylating and methylating agents were assessed in Encherichia coli strains that are defective in the adaptive response to alkylating agents, and the mechanism for its removal was characterized in vitro. Expand
Pathways of mutagenesis and repair in Escherichia coli exposed to low levels of simple alkylating agents.
TLDR
It is shown here that error-prone repair is responsible for the majority of mutants formed after a large dose of alkylating agent, but it is unlikely that it contributes significantly to mutagenesis during exposure to low concentrations of these chemicals. Expand
Repair and mutagenesis in Escherichia coli K-12 after exposure to various alkyl-nitrosoguanidines
The mutagenic and toxic effects of a series of N-alkyl-N'-nitro-N-nitrosoguanidines were examined in Escherichia coli K-12. The role of nucleotide excision repair, the SOS response, and the adaptiveExpand
Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents.
  • M. Volkert, D. C. Nguyen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
Both aidA and aidB share with adaptive response a common regulatory mechanism involving the ada gene, and the growth phase-dependent control of the aidB fusions, however, is unaffected by ada, suggesting that a second regulatory mechanism exists that controls only aidB. Expand
Multiple species of Bacillus subtilis DNA alkyltransferase involved in the adaptive response to simple alkylating agents
TLDR
The proposition that ada mutants can be classified into two groups is supported and extended; one is defective only in the inducible synthesis of O6-methylguanine:DNA methyltransferase (22-kDa protein), and the other is deficient in the adaptive response in toto. Expand
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