Adaptive response of escherichia coli to alkylation damage

@article{Volkert1988AdaptiveRO,
  title={Adaptive response of escherichia coli to alkylation damage},
  author={Michael R Volkert},
  journal={Environmental and Molecular Mutagenesis},
  year={1988},
  volume={11}
}
  • M. Volkert
  • Published 1988
  • Biology
  • Environmental and Molecular Mutagenesis
Treatment of cells with low levels of alkylating agents for extended periods of time causes them to become resistant to the lethal and mutagenic effects of subsequent high‐level challenge treatments with alkylating agents. This increased resistance has been called the adaptive response to alkylation damage and results from the induction of an alkylation‐specific DNA repair response. The adaptive response is most efficiently induced by methylating agents and is most effective against the lethal… 

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TLDR
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Quasi-Adaptive Response to Alkylating Agents in Escherichia coli: A New Phenomenon

TLDR
The new phenomenon extends the functional range of NO compounds to include a role in genetic signal transduction within the Ada response system in addition to similar roles in the SoxRS, SOS, and OxyR systems in E. coli.

The AidB Component of the Escherichia coli Adaptive Response to Alkylating Agents Is a Flavin-Containing, DNA-Binding Protein

TLDR
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...

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TLDR
It is reported that O6-MeG disappears from alkylated DNA after incubation with a crude enzyme fraction from adapted cells, although no concomitant release of the methyl group or theAlkylated base or nucleotide occurs, due to a previously unrecognised DNA repair mechanism involving enzyme-catalysed structural alteration of the alkylations.

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TLDR
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TLDR
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TLDR
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  • M. VolkertD. C. Nguyen
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
Both aidA and aidB share with adaptive response a common regulatory mechanism involving the ada gene, and the growth phase-dependent control of the aidB fusions, however, is unaffected by ada, suggesting that a second regulatory mechanism exists that controls only aidB.

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TLDR
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TLDR
A model for the molecular mechanism of adaptive response of Escherichia coli to alkylating agents is proposed, and a methylated form of Ada protein is prepared by an in vitro reaction and compared the activity with that of the normal, unmethylated form.
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