Adaptive randomization for multiarm comparative clinical trials based on joint efficacy/toxicity outcomes.

@article{Ji2009AdaptiveRF,
  title={Adaptive randomization for multiarm comparative clinical trials based on joint efficacy/toxicity outcomes.},
  author={Yuan Ji and Benjamin Nebiyou Bekele},
  journal={Biometrics},
  year={2009},
  volume={65 3},
  pages={876-84}
}
We present an outcome-adaptive randomization (AR) scheme for comparative clinical trials in which the primary endpoint is a joint efficacy/toxicity outcome. Under the proposed scheme, the randomization probabilities are unbalanced adaptively in favor of treatments with superior joint outcomes characterized by higher efficacy and lower toxicity. This type of scheme is advantageous from the patients' perspective because on average, more patients are randomized to superior treatments. We extend… CONTINUE READING