Adaptive protein evolution in Drosophila

  title={Adaptive protein evolution in Drosophila},
  author={N. G. Smith and A. Eyre-Walker},
  • N. G. Smith, A. Eyre-Walker
  • Published 2002
  • Biology, Medicine
  • Nature
  • For over 30 years a central question in molecular evolution has been whether natural selection plays a substantial role in evolution at the DNA sequence level. Evidence has accumulated over the last decade that adaptive evolution does occur at the protein level, but it has remained unclear how prevalent adaptive evolution is. Here we present a simple method by which the number of adaptive substitutions can be estimated and apply it to data from Drosophila simulans and D. yakuba. We estimate… CONTINUE READING
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