Adaptive mutation inEscherichia coli strain FC40

@article{Foster2008AdaptiveMI,
  title={Adaptive mutation inEscherichia coli strain FC40},
  author={Patricia L. Foster and William A. Rosche},
  journal={Journal of Genetics},
  year={2008},
  volume={78},
  pages={7-11}
}
Mutations can arise in static populations of cells that are subjected to nonlethal selective pressure, a phenomenon that has been called ‘adaptive mutation’. This phenomenon has been extensively studied in FC40, a strain ofEscherichia coli that cannot metabolize lactose (Lac−) but that reverts to lactose utilization (Lac+) when lactose is its sole energy and carbon source. The adaptive Lac+ mutations arise by two mutational processes: a recombination-dependent process that is highly active on… CONTINUE READING