Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing

@inproceedings{Selman2012AdaptiveMI,
  title={Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing},
  author={Mohammed Selman and Samar K. Dankar and Nicole Elise Forbes and Jian-Jun Jia and Earl G. Brown},
  booktitle={Emerging Microbes & Infections},
  year={2012}
}
Little is known about the processes that enable influenza A viruses to jump into new host species. Here we show that the non-structural protein1 nucleotide substitution, A374G, encoding the D125G(GAT→GGT) mutation, which evolved during the adaptation of a human virus within a mouse host, activates a novel donor splice site in the non-structural gene, hence producing a novel influenza A viral protein, NS3. Using synonymous 125G mutations that do not activate the novel donor splice site, NS3 was… CONTINUE READING
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