Adaptive mutation and cocolonization during Helicobacter pylori infection of gnotobiotic piglets.

@article{Akopyants1995AdaptiveMA,
  title={Adaptive mutation and cocolonization during Helicobacter pylori infection of gnotobiotic piglets.},
  author={Natalia S. Akopyants and Kathryn A. Eaton and Douglas E. Berg},
  journal={Infection and immunity},
  year={1995},
  volume={63 1},
  pages={116-21}
}
Clinical isolates of Helicobacter pylori, the gastric pathogen implicated in gastritis, peptic ulcers, and gastric cancer in humans, are diverse in traits likely to be important for colonization and disease. Here we report studies using a gnotobiotic piglet-H. pylori infection model to test for host-specific adaptation and to detect cocolonization by different strains. First, an H. pylori strain that initially had grown only weakly in piglets was adapted to them by spontaneous mutation and… CONTINUE READING

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