Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress.

@article{Hersh2004AdaptiveMA,
  title={Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress.},
  author={Megan N. Hersh and Rebecca G. Ponder and P J Hastings and Susan M Rosenberg},
  journal={Research in microbiology},
  year={2004},
  volume={155 5},
  pages={352-9}
}
The neo-Darwinists suggested that evolution is constant and gradual, and thus that genetic changes that drive evolution should be too. However, more recent understanding of phenomena called adaptive mutation in microbes indicates that mutation rates can be elevated in response to stress, producing beneficial and other mutations. We review evidence that, in Escherichia coli, two separate mechanisms of stress-induced genetic change occur that revert a lac frameshift allele allowing growth on… CONTINUE READING

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