Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture

@article{Chang2013AdaptiveMN,
  title={Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture},
  author={Hao Chang and A. Levchenko},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2013},
  volume={368}
}
  • Hao Chang, A. Levchenko
  • Published 2013
  • Biology, Medicine
  • Philosophical Transactions of the Royal Society B: Biological Sciences
    • Eukaryotic signalling networks underlying the cell's ability to sense the gradient of chemotactic cues frequently have the dual property of perfect adaptation to spatially homogeneous inputs, and persistent activation by inputs that are spatially graded. This property is also shared by bacterial chemotaxis networks, raising the question of whether these two types of chemotactic processes also have similar organization of the underlying biomolecular processes. Interestingly, perfect adaptation… CONTINUE READING
    View on Royal Society
    royalsocietypublishing.org
    13 Citations
    Background Citations
    7
    Methods Citations
    1

    Figures and Topics from this paper

    Figures

    Explore Further: Topics Discussed in This Paper

    13 Citations
    Citation Type

    Citation Type

    A computational model for how cells choose temporal or spatial sensing during chemotaxis
    • 4
    • PDF
    Adaptation through proportion.
    • 2
    • PDF
    Developmental Cell Perspective How to Understand and Outwit Adaptation
    • PDF
    Bridging the gap between modules in isolation and as part of networks: A systems framework for elucidating interaction and regulation of signalling modules.
    • 5
    • PDF
    Elastic Multi-scale Mechanisms: Computation and Biological Evolution
    • 6
    Distorted Biologic Mechanisms in Evolution and Model Extrapolation
    • PDF
    Distorted Biologic Mechanisms in Evolution and Model Extrapolation
    Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium
    • 9
    • PDF
    How to understand and outwit adaptation.
    • 27
    Design Constraints for Biological Systems That Achieve Adaptation and Disturbance Rejection
    • 5

    References

    SHOWING 1-10 OF 33 REFERENCES
    Robustness in bacterial chemotaxis
    • 1,085
    • PDF
    Robustness in simple biochemical networks
    • 1,406
    Incoherent Feedforward Control Governs Adaptation of Activated Ras in a Eukaryotic Chemotaxis Pathway
    • 127
    • PDF
    Modeling the Cell's Guidance System
    • 94
    • PDF
    Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils.
    • 389
    Modeling the chemotactic response of Escherichia coli to time-varying stimuli
    • 204
    • PDF
    Diverse Sensitivity Thresholds in Dynamic Signaling Responses by Social Amoebae
    • 80
    • Highly Influential
    Signal processing by the HOG MAP kinase pathway
    • 240
    • PDF
    The gradient-sensing mechanism in bacterial chemotaxis.
    • R. Macnab, D. Koshland
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1972
    • 701
    • PDF
    Robust perfect adaptation in bacterial chemotaxis through integral feedback control.
    • 948
    • PDF