• Biology, Medicine
• Published in
  Philosophical Transactions of…
  2013
• DOI:10.1098/rstb.2013.0117

Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture

@article{Chang2013AdaptiveMN,
  title={Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture},
  author={Hao Chang and Andre Levchenko},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2013},
  volume={368}
}

• Hao Chang, Andre Levchenko

Eukaryotic signalling networks underlying the cell's ability to sense the gradient of chemotactic cues frequently have the dual property of perfect adaptation to spatially homogeneous inputs, and persistent activation by inputs that are spatially graded. This property is also shared by bacterial chemotaxis networks, raising the question of whether these two types of chemotactic processes also have similar organization of the underlying biomolecular processes. Interestingly, perfect adaptation… CONTINUE READING

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