Adaptive molecular evolution for 13,000 phage generations: a possible arms race.

  title={Adaptive molecular evolution for 13,000 phage generations: a possible arms race.},
  author={Holly A. Wichman and Jack H. Millstein and J. J. Bull},
  volume={170 1},
Bacteriophage phiX174 was evolved on a continuous supply of sensitive hosts for 180 days ( approximately 13,000 phage generations). The average rate of nucleotide substitution was nearly 0.2% (11 substitutions)/20 days, and, surprisingly, substitutions accumulated in a clock-like manner throughout the study, except for a low rate during the first 20 days. Rates of silent and missense substitutions varied over time and among genes. Approximately 40% of the 71 missense changes and 25% of the 58… CONTINUE READING

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