Adaptive modelling of dose-response relationships using smoothing splines.

@article{Kirby2009AdaptiveMO,
  title={Adaptive modelling of dose-response relationships using smoothing splines.},
  author={Simon Kirby and Peter Colman and Mark K Morris},
  journal={Pharmaceutical statistics},
  year={2009},
  volume={8 4},
  pages={346-55}
}
We consider the use of smoothing splines for the adaptive modelling of dose-response relationships. A smoothing spline is a nonparametric estimator of a function that is a compromise between the fit to the data and the degree of smoothness and thus provides a flexible way of modelling dose-response data. In conjunction with decision rules for which doses to… CONTINUE READING