Adaptive group sequential designs for clinical trials: combining the advantages of adaptive and of classical group sequential approaches.

@article{Mller2001AdaptiveGS,
  title={Adaptive group sequential designs for clinical trials: combining the advantages of adaptive and of classical group sequential approaches.},
  author={H H M{\"u}ller and Helmut Sch{\"a}fer},
  journal={Biometrics},
  year={2001},
  volume={57 3},
  pages={886-91}
}
A general method is presented integrating the concept of adaptive interim analyses into classical group sequential testing. This allows the researcher to represent every group sequential plan as an adaptive trial design and to make design changes during the course of the trial after every interim analysis in the same way as with adaptive designs. The… CONTINUE READING