Adaptive evolution that requires multiple spontaneous mutations. I. Mutations involving an insertion sequence.

@article{Hall1988AdaptiveET,
  title={Adaptive evolution that requires multiple spontaneous mutations. I. Mutations involving an insertion sequence.},
  author={Barry G. Hall},
  journal={Genetics},
  year={1988},
  volume={120 4},
  pages={887-97}
}
Escherichia coli K12 strain chi 342LD requires two mutations in the bgl (beta-glucosidase) operon, bglR0----bglR+ and excision of IS103 from within bglF, in order to utilize salicin. In growing cells the two mutations occur at rates of 4 x 10(-8) per cell division and less than 2 x 10(-12) per cell division, respectively. In 2-3-week-old colonies on MacConkey salicin plates the double mutants occur at frequencies of 10(-8) per cell, yet the rate of an unselected mutation, resistance to valine… CONTINUE READING
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Showing 1-10 of 10 references

a Evolution on a petri dish

  • B. G. HALL
  • Evol . Biol .
  • 1982
Highly Influential
4 Excerpts

The evolution of DNA sequences in Excherichia coli

  • O. HESS
  • Phil . Trans . R . SOC . Lond . B
  • 1986

Observations on the formation of clones containing araBlacZ cistron fusions

  • J. B. SPOFFORD
  • Mol . Gen . Genet .
  • 1984

Studies on the mechanism of heterochromatic position effect at the rosy locus of Drosophila melanogaster

  • F. J. RYAN
  • Genetics
  • 1984

Transposon TNlO provides a promoter for transcription of adjacent sequences

  • P. H. CLARKE
  • Proc . Natl . Acad . Sci . USA
  • 1982

Transposable elements in prokaryotes

  • A. L. KOCH
  • 1981

Chromosomal mutation for citrate utilization in Escherichia coli K 12

  • B. G. HALL
  • J . Bacteriol .
1 Excerpt

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