Adaptive evolution of young gene duplicates in mammals.

  title={Adaptive evolution of young gene duplicates in mammals.},
  author={Mira V. Han and Jeffery P. Demuth and Casey L. McGrath and Claudio Casola and Matthew W. Hahn},
  journal={Genome research},
  volume={19 5},
Duplicate genes act as a source of genetic material from which new functions arise. They exist in large numbers in every sequenced eukaryotic genome and may be responsible for many differences in phenotypes between species. However, recent work searching for the targets of positive selection in humans has largely ignored duplicated genes due to complications in orthology assignment. Here we find that a high proportion of young gene duplicates in the human, macaque, mouse, and rat genomes have… CONTINUE READING
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