Adaptive evolution of the histone fold domain in centromeric histones.

  title={Adaptive evolution of the histone fold domain in centromeric histones.},
  author={Jennifer L Cooper and Steven Henikoff},
  journal={Molecular biology and evolution},
  volume={21 9},
Centromeric DNA, being highly repetitive, has been refractory to molecular analysis. However, centromeric structural proteins are encoded by single-copy genes, and these can be analyzed by using standard phylogenetic tools. The centromere-specific histone, CenH3, replaces histone H3 in centromeric nucleosomes, and is required for the proper distribution of chromosomes during cell division. Whereas histone H3s are nearly identical between species, CenH3s are divergent, with an N-terminal tail… CONTINUE READING

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