Adaptive evolution of small heat shock protein/alpha B-crystallin promoter activity of the blind subterranean mole rat, Spalax ehrenbergi.

@article{Hough2002AdaptiveEO,
  title={Adaptive evolution of small heat shock protein/alpha B-crystallin promoter activity of the blind subterranean mole rat, Spalax ehrenbergi.},
  author={R Barry Hough and Aaron Avivi and Judianne Davis and Alma Joel and Eviatar Nevo and Joram Piatigorsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 12},
  pages={
          8145-50
        }
}
Blind mole rats have degenerated subcutaneous eyes that are visually nonfunctional. In this investigation, we have compared the tissue specificity of the small heat shock protein (shsp)/alphaB-crystallin promoter of the mole rat superspecies, Spalax ehrenbergi, with that of the mouse. Earlier experiments showed that mouse shsp/alphaB-crystallin promoter/enhancer activity is high in the lens and moderate in the heart and skeletal muscle of transgenic mice. Here, we show in transgenic mouse… CONTINUE READING

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