Adaptive evolution of p53 thermodynamic stability.

  title={Adaptive evolution of p53 thermodynamic stability.},
  author={Kian Hoe Khoo and Antonina Andreeva and A. R. Fersht},
  journal={Journal of molecular biology},
  volume={393 1},
The thermodynamic stability of a protein plays an important role during evolution and adaptation in order to maintain a folded and active conformation. p53 is a tumour suppressor involved in the regulation of numerous genes. Human p53 has an unusually low thermodynamic stability and is frequently inactivated by oncogenic missense mutations. Here, we examined the thermodynamic and kinetic stability of p53 DNA binding domains from selected invertebrate and vertebrate species by differential… CONTINUE READING


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