Adaptive evolution and fixation of drug-resistant Plasmodium falciparum genotypes in pregnancy-associated malaria: 9-year results from the QuEERPAM study.

@article{Taylor2012AdaptiveEA,
  title={Adaptive evolution and fixation of drug-resistant Plasmodium falciparum genotypes in pregnancy-associated malaria: 9-year results from the QuEERPAM study.},
  author={Steve M. Taylor and Alejandro L. Antonia and Gaoqian Feng and Victor Mwapasa and Ebbie Chaluluka and Malcolm Edward Molyneux and Feiko O Ter Kuile and Stephen J Rogerson and Steven Richard Meshnick},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2012},
  volume={12 2},
  pages={282-90}
}
Sulfadoxine-pyrimethamine (SP) has been widely deployed in Africa for malaria control and molecular evidence of parasite drug-resistance is prevalent. However, the temporal effects on the selection of Plasmodium falciparum are not well understood. We conducted a retrospective serial cross-sectional study between 1997 and 2006 to investigate changes in drug… CONTINUE READING