Adaptive enrichment designs for clinical trials.

@article{Simon2013AdaptiveED,
  title={Adaptive enrichment designs for clinical trials.},
  author={Noah Simon and Richard Simon},
  journal={Biostatistics},
  year={2013},
  volume={14 4},
  pages={613-25}
}
Modern medicine has graduated from broad spectrum treatments to targeted therapeutics. New drugs recognize the recently discovered heterogeneity of many diseases previously considered to be fairly homogeneous. These treatments attack specific genetic pathways which are only dysregulated in some smaller subset of patients with the disease. Often this subset is only rudimentarily understood until well into large-scale clinical trials. As such, standard practice has been to enroll a broad range of… CONTINUE READING
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