Adaptive dose-finding: Proof of concept with type I error control.

  • Frank Miller
  • Published 2010 in Biometrical journal. Biometrische Zeitschrift


We consider an adaptive dose-finding study with two stages. The doses for the second stage will be chosen based on the first stage results. Instead of considering pairwise comparisons with placebo, we apply one test to show an upward trend across doses. This is a possibility according to the ICH-guideline for dose-finding studies (ICH-E4). In this article… (More)
DOI: 10.1002/bimj.200900222

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