Adaptive designs for subpopulation analysis optimizing utility functions

@inproceedings{Graf2015AdaptiveDF,
  title={Adaptive designs for subpopulation analysis optimizing utility functions},
  author={Alexandra Christine Graf and Martin Posch and Franz Koenig},
  booktitle={Biometrical journal. Biometrische Zeitschrift},
  year={2015}
}
If the response to treatment depends on genetic biomarkers, it is important to identify predictive biomarkers that define (sub-)populations where the treatment has a positive benefit risk balance. One approach to determine relevant subpopulations are subgroup analyses where the treatment effect is estimated in biomarker positive and biomarker negative… CONTINUE READING