Adaptive designs for identifying optimal biological dose for molecularly targeted agents.

@article{Zang2014AdaptiveDF,
  title={Adaptive designs for identifying optimal biological dose for molecularly targeted agents.},
  author={Yong Zang and J Jack Lee and Ying Yuan},
  journal={Clinical trials},
  year={2014},
  volume={11 3},
  pages={
          319-327
        }
}
Background Traditionally, the purpose of a dose-finding design in cancer is to find the maximum tolerated dose based solely on toxicity. However, for molecularly targeted agents, little toxicity may arise within the therapeutic dose range and the dose-response curves may not be monotonic. This challenges the principle that more is better, which is widely accepted for conventional chemotherapy. Methods We propose three adaptive dose-finding designs for trials evaluating molecularly targeted… CONTINUE READING

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