Adaptive clinical trial design.

  title={Adaptive clinical trial design.},
  author={Shein-chung Chow},
  journal={Annual review of medicine},
In recent years, the use of adaptive design methods in clinical trials based on accumulated data at interim has received much attention because of its flexibility and efficiency in pharmaceutical/clinical development. In practice, adaptive design may provide the investigators a second chance to modify or redesign the trial while the study is still ongoing. However, it is a concern that a shift in target patient population may occur after significant adaptations are made. In addition, the… CONTINUE READING

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