Adaptive changes in the responsiveness of adenylate cyclase to catecholamines.

@article{Perkins1979AdaptiveCI,
  title={Adaptive changes in the responsiveness of adenylate cyclase to catecholamines.},
  author={John P. Perkins and Ying Fu Su and T. Kendall Harden},
  journal={Drug and alcohol dependence},
  year={1979},
  volume={4 3-4},
  pages={279-94}
}
Exposure of the intact astrocytoma cell to isoproterenol not only causes the activation of adenylate cyclase and the accumulation of cyclic AMP but sets in motion a complicated series of events designed to down-regulate the system if exposure to the agonist is extended in time. We have identified at least three of these processes: (1) a rapid uncoupling of… CONTINUE READING